EMBL-EBI, a part of the European Molecular Biology Laboratory, is making over 200 million protein structures available to scientists worldwide through the AlphaFold Protein Structure Database. This database, launched in 2021 with 365,000 structure predictions, has since grown to over 200 million predictions, greatly expanding our understanding of biology. This free resource is a significant step forward in open data for the life sciences and will provide researchers with valuable information to help solve a wide range of problems. With data spanning genomics, proteins, small molecules, and more, EMBL-EBI is a key player in the field of big data in biology and is dedicated to benefiting humankind through scientific discoveries. This open access to vast amounts of protein structure predictions will undoubtedly advance research in the life sciences on a global scale. For more information, visit the AlphaFold Protein Structure Database.